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Diazepam se ne sme primenjivati kao monoterapija u terapiji depresije i anksioznosti udružene sa depresijom, jer kod ove grupe pacijenata može uzrokovati pojavu suicida.Esomeprazol inhibira CYP2C19 metabolički place diazepama. Istovremena primena esomeprazola produžava poluvreme eliminacije i povećava vrednosti PIK diazepama za približno 80%.

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